PTEN Hamartoma Tumor Syndrome arises as a result of a PTEN Gene Mutation. PTEN HAMARTOMA TUMOR SYNDROME (PHTS)- is an under-diagnosed hereditary cancer syndrome affecting more than one in two-hundred thousand worldwide. Due to advocacy efforts, more than 1500 PHTS patients have been identified, and the number continues to grow. PTEN is the second most commonly mutated tumor suppressor in human cancer, with an estimated 30% harboring somatic PTEN mutations (Nakamura et al., 2000; Simpson and Parsons, 2001). Additionally, un-regulated PTEN expression has been implicated in other non-oncogenic illnesses, including Alzheimer's disease and autism (Knafo et al., 2016 Zhou and Parada, 2012). We have the opportunity to advance research and treatment options for our families which will significantly improve the quality of life for our patients and reduce cancer risks.
Some of our children are very ill with severe tumor overgrowth. We believe that there are therapeutic options might save their lives, and hope that you will support our efforts. Our children and grandchildren deserve a life free of cancer and autism or other neurologic diseases. You can help us make a difference with a small donation.