The ALS CURE Project
The ALS CURE Project was founded by Stephen Piscotty and Mike Piscotty following the passing of Gretchen Piscotty who moved on to her perfect heavenly form on May 6, 2018. The ALS CURE Project has one goal: rid the world of ALS so no one has to suffer Gretchen's fate. We are a 100% volunteer organization raising funding to conduct the vital ALS research necessary to successfully complete our project of curing ALS. Our research focus is directed by our Research Council of top ALS specialists and we partner with top research labs using super computers and articial intelligence.
The ALS CURE Project is leading ALS research to understand what starts the ALS disease and what causes it to continue until death. This is known as the ALS disease mechanism of action and is 100% fatal. As horrible as the Covid-19 virus is, patients with the ALS death sentence would gladly trade their condition for a chance to survive Covid-19. Over 20,000 people in the US currently have ALS. There are approximately 6,000 new cases each year, and 6,000 deaths. It is imperative that ALS research continue during this Covid-19 crisis.
Covid-19 Impacts Fund Raising
The ALS CURE Project board of directors approved a grant for a project to discover the ALS disease mechanism in February 2020 following the recommendation of our ALS CURE Project Research Council. This was based upon an expected revenue stream from various fund raisers such as golf tournaments, gala dinners and auctions. Due to the Covid-19 crisis, these events have been indefinitely postponed. Funds raised from this campaign will support research on the ALS Disease mechanism which is critical first step to discovering a cure for the ALS.
Key to understanding the ALS Disease mechanism is figuring out the key physical workings of ALS cellular pathology. The initial focus will be on the formation of the aberrant TAR DNA-binding protein 43 (TDP-43) inclusions or clusters that transition into pathological, amyloid-like fibrils. This clustered form of TDP-43 is present in over 95% of ALS patients and will be the initial focus of modeling simulations.
Understanding the ALS Disease mechamism is a vital first step towards a cure for ALS.
Thank you for you support.
Mike Piscotty, President ALS CURE Project, alscure.net, firstname.lastname@example.org